MicroRNA Targeting to Modulate Tumor Microenvironment
نویسندگان
چکیده
منابع مشابه
MicroRNA Targeting to Modulate Tumor Microenvironment
Communication between stromal cells and tumor cells initiates tumor growth, angiogenesis, invasion, and metastasis. Stromal cells include cancer-associated fibroblasts, tumor-associated macrophages, pericytes, endothelial cells, and infiltrating immune cells. MicroRNAs (miRNAs) in the tumor microenvironment have emerged as key players involved in the development of cancer and its progression. m...
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In recent years, there is an increasing attention on the impact of the tumor microenvironment (TME) on tumor initiation, progression, and metastasis (1). Malignant tumor cells and non-malignant stromal cells actively interact with each other and thereby create a tumor-supportive microenviron-ment (2). TME is composed of extracellular matrix and several cell types, such as cancer-associated fibr...
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ژورنال
عنوان ژورنال: Frontiers in Oncology
سال: 2016
ISSN: 2234-943X
DOI: 10.3389/fonc.2016.00003